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c , SK-N-SH, SH-SY5Y, HaCaT, and THP1 cells were stimulated with IFN (25 ng/mL) for 6 h, and total RNA was isolated for analysis of MXA transcripts by RT-qPCR (n = 3 biological replicates)

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Inadequate glutathione can lead to an imbalance of molecules called free radicals or reactive oxygen species (ROS) that damage cells, proteins, fats, and DNA

Due to the high reactivity of Prx and Gpx (and abundance in the case of Prx), direct oxidation of GSH and other important redox-regulated proteins (like GAPDH or protein tyrosine phosphatase) are prevented up till the concentration of H 2 O 2 reaches tens of M -s, and hence, the redox signal that involves H 2 O 2 is most likely transmitted via Prx and/or Gpx

Romanov, V